Tag: fibrosis
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MASLD: Managing disease progression in metabolic liver disease
Understanding MASLD and MASH Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing health concern tied to obesity, insulin resistance, and metabolic syndrome. In MASLD, fat accumulates in the liver, which can progress to metabolic dysfunction-associated steatohepatitis (MASH) when inflammation and liver cell injury accompany fat deposition. This progression increases the risk of fibrosis, cirrhosis,…
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Resolution Therapeutics Unveils Early MATCH Phase II Data; Regenerative Macrophage Therapy Shows Promise for Cirrhosis at AASLD 2025
Groundbreaking DATA at AASLD 2025 Resolution Therapeutics presented new clinical and preclinical data at AASLD 2025 highlighting the potential of Regenerative Macrophage Therapy for cirrhosis. The company reported early improvements in liver function in the MATCH Phase II study using non-engineered macrophages, with associations to favorable long-term clinical outcomes. These findings position Resolution’s macrophage-based approach…
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Blocking key protein restores healthy lung function and reduces fibrosis in mice
Blocking a cellular switch to halt lung scarring Pulmonary fibrosis is a devastating lung disease where the tissue thickens and scar tissue progressively limits oxygen delivery. In a new study from UC San Francisco, researchers have identified a pivotal cellular switch that drives this damaging process and demonstrated that blocking it can protect lung function…
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Checkpoint inhibitors reveal tissue repair role, offering hope for chronic wounds
Unveiling a new function for a familiar immune brake Checkpoint inhibitors are well known for their role in cancer therapy, where they release the immune system’s brakes to attack tumor cells. In a surprising twist, researchers from the University of Zurich (UZH) have uncovered a second, equally important function: TIGIT, a checkpoint protein, promotes tissue…
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Checkpoint Inhibitor TIGIT Promotes Tissue Repair
New role for checkpoint inhibitors in tissue healing Checkpoint inhibitors are best known for unleashing the immune system against cancer. A surprising new perspective emerging from researchers at the University of Zurich (UZH) shows that one of these inhibitors, TIGIT, also plays a vital part in tissue repair. Published in Nature Immunology, the study reveals…
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TIGIT: Immune Checkpoint Promoter of Tissue Healing Could Change Fibrosis and Wound Care
Groundbreaking finding: TIGIT helps tissue repair Researchers at the University of Zurich (UZH) have uncovered a surprising role for the immune checkpoint inhibitor TIGIT beyond its well-known function as a cancer therapy target. In a study led by Nicole Joller, the team demonstrated that TIGIT not only helps regulate immune responses during infections but also…
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Checkpoint inhibitors aid tissue repair, offering new hope for chronic wounds
Summary: A new role for checkpoint inhibitors in tissue repair Checkpoint inhibitors, best known for unleashing the immune system against cancer, may also help heal damaged tissues. Researchers at the University of Zurich (UZH) have identified a previously unknown function of one such inhibitor, TIGIT: it promotes tissue repair after viral infection. The discovery, published…
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TIGIT Promotes Tissue Healing: A New Role for Immune Checkpoints
Unlocking a Hidden Role for Immune Checkpoints Immune checkpoint inhibitors are best known as cancer therapies that unleash the body’s defenses against tumors. A team from the University of Zurich (UZH) has uncovered a surprising new function for one of these molecules: TIGIT, a surface receptor on immune cells, also promotes tissue healing after viral…
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TIGIT Immune Checkpoint Promotes Tissue Healing and Regeneration
Overview: A new role for an immune checkpoint Immune checkpoint inhibitors have transformed cancer therapy by releasing the brakes on the immune system. A surprising new finding from researchers at the University of Zurich (UZH) reveals that one such brake, TIGIT, does more than help tumor-fighting immune cells—it also promotes tissue healing. This discovery could…