Tag: estradiol
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HPO Axis & Brain Aging: Ovarian Disorders & Neurodegeneration
Understanding the HPO Axis in Female Health The hypothalamic-pituitary-ovarian (HPO) axis is a finely tuned endocrine feedback loop that governs ovulation and reproductive function in female vertebrates. Proper balance relies on the regulated secretion of sex steroids by the ovarian follicle to inhibit pulsatile release of gonadotropins from the pituitary. Disruptions in any component of…
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HPO Axis and Brain Aging: Ovarian Disorders Explained
Introduction: Connecting the HPO Axis to Brain Aging The hypothalamic‑pituitary‑ovarian (HPO) axis sits at the center of female reproductive health, orchestrating ovulation through a delicate balance of hormones. Recent reviews highlight how disruptions in this axis not only drive ovarian disorders such as menopause, primary ovarian insufficiency (POI), and polycystic ovary syndrome (PCOS) but may…
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The HPO Axis, Ovarian Disorders, and Brain Aging: Connecting Reproductive Health to Neurodegeneration
Understanding the HPO Axis and Its Role in Reproductive Health The hypothalamic-pituitary-ovarian (HPO) axis is a finely tuned endocrine system that governs female reproduction. It starts in the hypothalamus, where gonadotropin-releasing hormone (GnRH) prompts the pituitary to secrete luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones, in turn, regulate ovarian follicle development and the…
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MSU Launches $3.7 Million Study on Perimenopause and Mental Health Risks
Groundbreaking Grant Fuels New Look at Perimenopause and Mental Health A landmark $3.7 million grant from the National Institute of Mental Health is enabling a focused investigation into perimenopause, a life stage that has long been overlooked in medical research. Researchers at Michigan State University’s Department of Psychology—led by MSU Research Foundation Professor Kelly Klump,…
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MSU study links perimenopause hormones to mental health outcomes with $3.7M grant
New research grant launches comprehensive study of perimenopause and mental health A landmark $3.7 million grant from the National Institute of Mental Health is enabling Michigan State University researchers to investigate the understudied period of perimenopause and its potential impact on mental health. The study aims to uncover how hormonal fluctuations during midlife may influence…