Tag: ER stress
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Calcium Signaling: A Key Regulator of Protein Quality in the Endoplasmic Reticulum
Introduction: Calcium’s Pivotal Role in the ER Calcium (Ca2+) is more than a universal messenger in the cell; it is a critical regulator of how proteins are folded and quality-checked inside the endoplasmic reticulum (ER). The ER is the cellular workshop where most secretory and membrane proteins acquire their correct structure before being dispatched to…
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ER Stress Biomarkers in COPD: Key Indicators for Management
Introduction Chronic obstructive pulmonary disease (COPD) encompasses a spectrum of chronic inflammatory lung diseases characterized by persistent airflow limitation and progressive decline in lung function. Beyond traditional risk factors like tobacco exposure, accumulating evidence highlights the role of cellular stress responses—particularly endoplasmic reticulum (ER) stress—in COPD pathogenesis. ER stress activates the unfolded protein response (UPR),…
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ER Stress-Related Biomarkers in COPD: Unlocking New Insights for Diagnosis and Therapy
Understanding ER Stress and COPD Chronic obstructive pulmonary disease (COPD) is a complex, heterogeneous condition marked by persistent inflammation and progressive decline in lung function. Recent research highlights the role of endoplasmic reticulum (ER) stress as a key cellular stress response in COPD. When misfolded proteins accumulate in the ER, a signaling cascade known as…
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ER Stress Biomarkers in COPD: Key Indicators of Disease Activity
Introduction to ER Stress and COPD Chronic obstructive pulmonary disease (COPD) is a heterogeneous respiratory condition marked by persistent inflammation, airway remodeling, and progressive loss of lung function. In recent years, researchers have turned to cellular stress pathways to better understand COPD pathogenesis. A central player is endoplasmic reticulum (ER) stress, a cellular state triggered…