Introduction Tick-borne diseases remain a major challenge for beef cattle in tropical regions. The enzootic stability of Theileria- and Babesia-caused infections depends on exposure levels to pathogens like Anaplasma marginale, Babesia bovis, and Babesia bigemina, balanced against tick burdens. This study investigates whether strategic use of fluralaner (Exzolt® 5%) affects enzootic stability in crossbred beef…