Tag: DNA repair
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Evolutionary mutation in cGAS enhances naked mole-rat DNA repair
Unlocking a Cellular Secret: cGAS and the Naked Mole-Rat’s Longevity The naked mole-rat, a small, wrinkled rodent native to East Africa, has long puzzled scientists with a lifespan approaching four decades—remarkably longer than similarly sized mammals. A new line of research suggests that a cellular protein known for signaling immune responses to DNA damage may…
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Genetic Link to Osteosarcoma Found: SMARCAL1 Gene Inheritance Raises Risk in Children
Breakthrough in Pediatric Cancer Genetics A collaborative study led by researchers at Cleveland Clinic Children’s has identified an inherited genetic factor that may elevate the risk of osteosarcoma, the most common malignant bone tumor in children and young adults. Published in the Journal of Clinical Oncology, the work analyzed genetic data from thousands of cancer…
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Genetic Link Identified: SMARCAL1 Mutations Raise Osteosarcoma Risk in Children
Groundbreaking discovery links SMARCAL1 to pediatric osteosarcoma A team from Cleveland Clinic Children’s has identified a previously unknown genetic factor that may increase the risk of developing osteosarcoma, the most common malignant bone tumor in children and young adults. Published recently in the Journal of Clinical Oncology, the study analyzed genetic data from thousands of…
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Cleveland Clinic Team Uncovers Genetic Link to Osteosarcoma
Groundbreaking discovery ties SMARCAL1 gene to pediatric osteosarcoma A team at Cleveland Clinic Children’s has identified a genetic factor that may increase the risk of developing osteosarcoma, the most common malignant bone tumor in children and young adults. The study, recently published in the Journal of Clinical Oncology, analyzed genetic data from nearly 6,000 children…
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Naked Mole Rats Reveal Genetic Secret to Long Life
New DNA Repair Twist Helps Naked Mole Rats Reach Extraordinary Ages Naked mole rats have long puzzled scientists with their remarkable longevity and resilience to age-related diseases. A new study published in Science brings a fresh and surprising insight: these subterranean rodents appear to have rewired a DNA damage response pathway in a way that…
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Naked Mole Rats Reveal DNA Repair Clues to Longevity
Unveiling a Longevity Mystery Naked mole rats are far from ordinary rodents. These hairless, burrowing creatures have fascinated scientists for decades with lifespans that outpace other rodents and a remarkable resistance to age-related diseases. A new study, published in Science and led by researchers at Tonji University in Shanghai, sheds light on a genetic secret…
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Naked Mole Rats Hint at a DNA Repair Blueprint for Longer Life
Introduction: A surprising secret of the long-lived rodent Among the animal kingdom’s quirkiest residents, naked mole rats stand out: hairless, nearly sausage-shaped subterranean creatures with sharp front teeth. More than just oddball characters in a wildlife documentary, they are the subject of a scientific breakthrough about aging. A study published in Science highlights a genetic…
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Cancer Cells’ Hidden Power Source: NAMs Boost DNA Repair Under Mechanical Stress
Unveiling a Hidden Power Source in Cancer Cells A groundbreaking study from the Centre for Genomic Regulation (CRG) in Barcelona reveals that cancer cells possess a rapid, localized energy boost when they are squeezed through tight spaces. In experiments using a specialized microscope that compresses living cells to three microns wide, researchers observed a dramatic,…
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Cancer Cells’ Hidden Power Source Revealed
Introduction: A surprising energy boost under pressure Scientists have uncovered a surprising mechanism that helps cancer cells survive the brutal mechanical gauntlets they must run to spread through the body. When cancer cells squeeze through dense tumor matrices, pores in blood vessels, and the bloodstream itself, they encounter intense physical stress. A team at the…
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Miscarriages, Down Syndrome, and Infertility Linked to Hidden DNA Process
Unveiling a hidden DNA process in reproduction For years, scientists have known that errors in chromosome numbers can derail pregnancy, leading to miscarriages or conditions such as Down syndrome. Now researchers are shining a light on a set of intricate, often unseen molecular steps that govern how eggs and sperm inherit their chromosomal baggage. The…