Tag: DNA repair
-
Short-Sleeping Mexican Cavefish: DNA Damage Without Aging Signs
Introduction Sleep is a fundamental behavior across the animal kingdom, shaping metabolism, learning, and longevity. A surprising line of inquiry has emerged from the study of the Mexican cavefish, Astyanax mexicanus, a species split between surface-dwelling and cave-dwelling populations. In particular, some cave populations exhibit markedly reduced sleep. Recent research now reveals a striking paradox:…
-
Short-Sleeping Mexican Cavefish Show Elevated DNA Damage Without Apparent Aging
Overview: A surprising link between sleep, DNA damage, and aging In an intriguing twist on the sleep–aging paradigm, researchers studying the Mexican cavefish (Astyanax mexicanus) have observed elevated DNA damage in individuals that sleep significantly less than their surface-dwelling relatives. Despite the uptick in DNA lesions, these short-sleeping cavefish do not exhibit the typical hallmarks…
-
New MAEA Function Could Tip the Scales in Chemotherapy Resistance
Groundbreaking discovery: MAEA’s unexpected role in DNA repair A University of Alberta research team has identified a surprising new function for MAEA (macrophage erythroblast attacher), a protein once thought to be primarily involved in red blood cell development. The scientists report in Science Advances that MAEA also plays a critical role in DNA repair and…
-
New MAEA function could help overcome chemo resistance in cancer treatment
New MAEA function in DNA repair offers a potential route to overcoming chemotherapy resistance A University of Alberta research team has identified a surprising new role for a protein once thought to be linked primarily to red blood cell development. The protein, macrophage erythroblast attacher (MAEA), appears to help regulate DNA repair and cell replication.…
-
MAEA Protein’s New Role Could Boost Chemotherapy Response
New findings reveal MAEA’s unexpected function in DNA repair and cancer therapy A University of Alberta research team has uncovered a surprising new role for the MAEA protein, historically associated with red blood cell development and linked to developmental disorders. In a study published in Science Advances, the researchers show that MAEA also helps control…
-
Four Mutations that Help Naked Mole Rats Fix DNA and Live Longer
Introduction: A Tiny Rodent with Remarkable Longevity The naked mole rat (Heterocephalus glaber) is a small, hairless rodent native to East Africa famed for living up to 37 years—almost ten times longer than mammals of similar size. Researchers have long suspected that its longevity stems from genetic and cellular strategies that protect DNA, the blueprint…
-
Four mutations in naked mole rats’ cGAS improve DNA repair and longevity
How naked mole rats defy ageing The naked mole rat (Heterocephalus glaber) is a small, hairless rodent native to East Africa famed for living up to about 37 years—nearly ten times longer than mammals of similar size. For years, scientists have wondered what molecular tricks these creatures use to keep their DNA intact as the…
-
Four Mutations in Naked Mole Rats Extend DNA Repair and Longevity
New twist in aging science: naked mole rats and DNA repair The naked mole rat (Heterocephalus glaber) is not just famous for living up to about 37 years—nearly ten times longer than mammals of similar size. A groundbreaking study published in Science reveals a surprising mechanism behind this longevity: four amino acid changes in a…
-
Mutations in cGAS May Boost DNA Repair and Longevity in Naked Mole-Rats
Intro: A Hidden Genetic Edge for Longevity Why do naked mole-rats live so long, especially when compared with other rodents? A new study points to a subtle molecular difference that may help explain their remarkable genome stability. Researchers have identified specific evolutionary mutations in the DNA sensor cGAS (cyclic GMP-AMP synthase) that appear to bolster…
-
Four Amino Acids Shape Naked Mole-Rat DNA Repair and Longevity
Unraveling a Longevity Secret: cGAS in Naked Mole-Rats For decades, naked mole-rats have puzzled scientists with their unusually long lifespans and robust genome maintenance. Reaching nearly 40 years in the wild, they outlive many rodents of similar size. A new line of inquiry suggests that subtle changes in a single enzyme of the innate immune…