Tag: disease susceptibility
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Bovine Paratuberculosis RNA-Seq: Deleterious Variants Identified
Overview: Using RNA-Seq to Elucidate Genetic Susceptibility to Bovine Paratuberculosis Bovine paratuberculosis, a chronic intestinal disease caused by Mycobacterium avium subspecies paratuberculosis (MAP), poses significant economic and animal welfare challenges in cattle herds worldwide. Recent advances in RNA sequencing (RNA-Seq) enable researchers to explore the full transcriptome of affected and at-risk animals, with a focus…
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Whole-transcriptome identification of deleterious variants in candidate genes linked to bovine paratuberculosis
Overview Paratuberculosis, a chronic enteric disease caused by Mycobacterium avium subspecies paratuberculosis (MAP), poses significant economic and welfare challenges in cattle. Recent advances in RNA-Sequencing (RNA-Seq) have enabled researchers to move beyond expression profiling and toward the discovery of coding sequence variants that may influence disease susceptibility. In particular, whole-transcriptome analyses can identify deleterious variants…