Tag: DENV-2
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Bridging Gaps in Dengue Surveillance: Addressing Sylvatic DENV-2 Misclassification in RT-qPCR Assays
Introduction: The surveillance blind spot in dengue diagnostics Dengue viruses are routinely monitored through molecular serotyping assays that identify circulating serotypes in patient samples. Recent work by Suppiah and colleagues highlights a significant blind spot: sylvatic dengue virus type 2 (DENV-2) strains are increasingly misclassified as “Undetermined Serotype” when using common commercial RT-qPCR serotyping assays.…
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Systematic misclassification of sylvatic dengue virus 2 (DENV-2) infections as “undetermined serotype”: implications for RT-qPCR dengue surveillance
Overview: An emerging blind spot in dengue diagnostics Recent correspondence highlights a critical flaw in routine dengue molecular surveillance: sylvatic dengue virus 2 (DENV-2) infections are being misclassified as “Undetermined Serotype” by commercial serotyping assays. This misclassification mirrors prior reports of assay failure against sylvatic DENV-2 strains, notably in Senegal, West Africa, suggesting a broader,…
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Addressing Systematic Misclassification of Sylvatic DENV-2 in Dengue RT-qPCR Surveillance
Summary Recent findings highlight a critical flaw in routine dengue surveillance: sylvatic dengue virus 2 (DENV-2) infections are being misclassified as “Undetermined Serotype” by commercial molecular serotyping assays. This misclassification stems from the noninclusion of sylvatic DENV-2 strains in current diagnostic panels, masking the true viral diversity circulating in populations. The consequence is a blind…