Tag: cSNPs
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Bovine Paratuberculosis: Deleterious Variants by RNA-Seq
Understanding the Challenge: Paratuberculosis in Cattle Bovine paratuberculosis, caused by Mycobacterium avium subsp. paratuberculosis (MAP), is a chronic intestinal disease that affects dairy and beef cattle worldwide. It impairs productivity, reduces milk yield, and presents significant economic and welfare concerns for producers. While environmental and management factors influence infection, host genetics also plays a pivotal…
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Whole-transcriptome identification of deleterious variants in candidate genes linked to bovine paratuberculosis
Overview Paratuberculosis, a chronic enteric disease caused by Mycobacterium avium subspecies paratuberculosis (MAP), poses significant economic and welfare challenges in cattle. Recent advances in RNA-Sequencing (RNA-Seq) have enabled researchers to move beyond expression profiling and toward the discovery of coding sequence variants that may influence disease susceptibility. In particular, whole-transcriptome analyses can identify deleterious variants…