Tag: Cryo-electron microscopy
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New protein insights pave way for malaria transmission-blocking vaccines
New protein insights offer a path to blocking malaria transmission Malaria remains a global health challenge, infecting hundreds of millions and causing hundreds of thousands of deaths each year. While existing vaccines reduce the risk of infection, they do not fully prevent the parasite from spreading from person to person via mosquitoes. A multinational team…
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New insights into malaria proteins offer pathway to blocking parasite transmission
Unlocking the blueprint for blocking malaria transmission Researchers have made a pivotal advance in the fight against malaria by revealing the detailed structures of two of the parasite’s surface proteins. Using millions of high-resolution images gathered with cryo-electron microscopy, scientists from Radboud university medical center in the Netherlands and The Hospital for Sick Children Research…
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Cryo-imaging Breakthrough Reveals Thick Biological Structures with Greater Clarity
Overview: A New Window into Thick Biological Samples Cryo-imaging has long promised a clearer view of biological materials in their near-native state. Traditional electron microscopy, while superb for isolated molecules, struggles with thicker samples. A Cornell-led team has unveiled a transformative method—tilt-corrected bright-field scanning transmission electron microscopy (tcBF-STEM)—that delivers higher contrast and dramatically increased efficiency…
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Cryo-imaging Reveals Deeper View of Thick Biological Materials
A New Window into Thick Biological Samples Cryo-imaging has taken a notable leap forward with a method called tilt-corrected bright-field scanning transmission electron microscopy (tcBF-STEM). Developed by a team at Cornell, this technique enables high-contrast imaging of thick biological materials that were previously challenging to study with electron microscopy. By rethinking how detectors capture electrons…