Overview Antibiotic de-escalation—reducing or stopping broad-spectrum antibiotics (BSA) as patient condition improves—has become a cornerstone of antimicrobial stewardship. Emerging evidence specifically highlights its benefits for patients with community-onset sepsis who are clinically stable and lack cultures positive for multidrug-resistant organisms (MDROs). When clinicians consider de-escalation by day 4, several favorable outcomes emerge, including shorter courses…