Tag: clonal hematopoiesis
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Non-DNMT3A CHIP Variants Linked to Higher Heart Failure Risk in Older Adults
Overview: CHIP and its Subtypes Clonal hematopoiesis of indeterminate potential (CHIP) is a condition in which blood-forming stem cells acquire somatic mutations and expand clonally. With age, CHIP becomes more common, and it has been associated with a range of cardiovascular and hematologic outcomes. While DNMT3A is among the most frequently mutated CHIP genes, a…
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Non-DNMT3A CHIP Variants Elevate Heart Failure Risk in Older Adults
What is CHIP and why it matters? Clonal hematopoiesis of indeterminate potential (CHIP) describes a mosaic of blood cells that carry somatic mutations, typically acquired with age. While many CHIP mutations are harmless in themselves, certain gene variants are increasingly associated with adverse cardiovascular outcomes. A growing body of research highlights how CHIP can influence…
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Non-DNMT3A CHIP Variants Linked to Higher Incident Heart Failure Risk in Older Adults
Understanding CHIP and Its Relevance to Heart Health Clonal hematopoiesis of indeterminate potential (CHIP) describes the expansion of blood-forming stem cells that carry genetic mutations. While CHIP becomes more common with age, not all mutations carry the same health risk. A growing body of research suggests that specific CHIP subtypes may influence cardiovascular outcomes, including…