Tag: checkpoint inhibitors
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Switching Immune-Cold Tumors to Immune-Hot: A Breakthrough Path to Durable Cancer Immunity
Turning the Tide on Immune-Cold Tumors In a pivotal study published in Nature Immunology, scientists reveal a strategy that could make aggressive, immune-suppressive tumors more vulnerable to the body’s defenses. Funded by the National Cancer Institute/NIH, the research builds on prior work in breast cancer to show that transforming the tumor microenvironment can awaken a…
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Switching Immune Cold Tumors to Immune Hot: A Breakthrough in Cancer immunotherapy
Overview: Turning immune-cold tumors into immune-hot targets In a significant advance for cancer immunotherapy, researchers have identified a strategy to reprogram immune-cold tumors—those that typically evade detection—into immune-hot tumors that recruit and coordinate immune cells to attack cancer. The study, recently published in Nature Immunology, builds on decades of work to harness the body’s own…
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Researchers Discover a Switch that Transforms Immune-Cold Tumors into Immune-Hot, Boosting Cancer Therapy
Transforming Immune-Cold Tumors into Immune-Active Targets Cancer research has long grappled with tumors that evade the body’s defenses. A recent study published in Nature Immunology, backed by the National Cancer Institute/NIH, reports a promising strategy to convert these immune-cold tumors into immune-hot ones. By priming the tumor environment with immune-activating signals, researchers observed a robust,…
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Checkpoint inhibitors reveal tissue repair role, offering hope for chronic wounds
Unveiling a new function for a familiar immune brake Checkpoint inhibitors are well known for their role in cancer therapy, where they release the immune system’s brakes to attack tumor cells. In a surprising twist, researchers from the University of Zurich (UZH) have uncovered a second, equally important function: TIGIT, a checkpoint protein, promotes tissue…