Tag: cGAS
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Four Mutations that Help Naked Mole Rats Fix DNA and Live Longer
Introduction: A Tiny Rodent with Remarkable Longevity The naked mole rat (Heterocephalus glaber) is a small, hairless rodent native to East Africa famed for living up to 37 years—almost ten times longer than mammals of similar size. Researchers have long suspected that its longevity stems from genetic and cellular strategies that protect DNA, the blueprint…
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Four mutations in naked mole rats’ cGAS improve DNA repair and longevity
How naked mole rats defy ageing The naked mole rat (Heterocephalus glaber) is a small, hairless rodent native to East Africa famed for living up to about 37 years—nearly ten times longer than mammals of similar size. For years, scientists have wondered what molecular tricks these creatures use to keep their DNA intact as the…
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Four Mutations in Naked Mole Rats Extend DNA Repair and Longevity
New twist in aging science: naked mole rats and DNA repair The naked mole rat (Heterocephalus glaber) is not just famous for living up to about 37 years—nearly ten times longer than mammals of similar size. A groundbreaking study published in Science reveals a surprising mechanism behind this longevity: four amino acid changes in a…
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Mutations in cGAS May Boost DNA Repair and Longevity in Naked Mole-Rats
Intro: A Hidden Genetic Edge for Longevity Why do naked mole-rats live so long, especially when compared with other rodents? A new study points to a subtle molecular difference that may help explain their remarkable genome stability. Researchers have identified specific evolutionary mutations in the DNA sensor cGAS (cyclic GMP-AMP synthase) that appear to bolster…
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Four Amino Acids Shape Naked Mole-Rat DNA Repair and Longevity
Unraveling a Longevity Secret: cGAS in Naked Mole-Rats For decades, naked mole-rats have puzzled scientists with their unusually long lifespans and robust genome maintenance. Reaching nearly 40 years in the wild, they outlive many rodents of similar size. A new line of inquiry suggests that subtle changes in a single enzyme of the innate immune…
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Evolutionary mutation in cGAS enhances naked mole-rat DNA repair
Unlocking a Cellular Secret: cGAS and the Naked Mole-Rat’s Longevity The naked mole-rat, a small, wrinkled rodent native to East Africa, has long puzzled scientists with a lifespan approaching four decades—remarkably longer than similarly sized mammals. A new line of research suggests that a cellular protein known for signaling immune responses to DNA damage may…