Tag: cancer metabolism
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Metastasis mapping: nutrient availability in breast cancer
Understanding how nutrients steer breast cancer spread Breast cancer does not spread uniformly. While tumor cells can invade many tissues, their ability to colonize different organs depends on a complex set of factors. Recent work summarized under the title “Nutrient requirements of organ-specific metastasis in breast cancer” highlights a growing understanding: the microenvironment’s nutrient landscape…
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Mapping Metastasis: How Nutrient Availability Shapes Breast Cancer’s Spread
Understanding the Role of Nutrients in Breast Cancer Metastasis Breast cancer can spread (metastasize) to multiple organs, yet the reasons behind why certain sites become preferred targets remain unclear. A growing body of research is revealing that the nutrient landscape of distant organs—what nutrients are plentiful, and how tumors tap into them—plays a pivotal role…
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Dual Role of SLC7A11 in Colorectal Cancer Ferroptosis: A Molecular Balancing Act
Overview: Ferroptosis in Colorectal Cancer Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide. In recent years, ferroptosis—a regulated form of cell death driven by iron-dependent lipid peroxidation—has emerged as a promising target for cancer therapy. Central to the ferroptosis axis is SLC7A11, a key component of system xc− that imports cystine in…
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The Dual Role of SLC7A11 in Colorectal Cancer Ferroptosis: A Molecular Tug-of-War
Understanding Ferroptosis and SLC7A11 in Colorectal Cancer Colorectal cancer (CRC) remains a major global health challenge, driven by complex metabolic and genetic alterations. A relatively new area of cancer biology—ferroptosis—refers to an iron-dependent form of regulated cell death triggered by lipid peroxidation. At the center of this process lies SLC7A11, a cystine/glutamate antiporter, which plays…
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BATF2: Glutamine-Driven Silencing of a Novel Tumor Suppressor in Head and Neck Cancer
Introduction A groundbreaking study from researchers at The University of Texas MD Anderson Cancer Center reveals that BATF2, a newly identified tumor suppressor gene, is silenced by metabolic factors in the tumor microenvironment. Specifically, glutamine appears to suppress BATF2 activity, dampening the immune response against head and neck cancer in five preclinical models. This discovery…