Tag: cancer genetics
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Single-Chromosome Sequencing in Human Cancers: Key Genes and Insights
Introduction: A focused lens on cancer genomics The field of cancer genetics is rapidly evolving, with researchers seeking methods that offer high-resolution insights while managing complexity. Single-chromosome sequencing represents a focused approach that targets individual chromosomes to reveal mutations, structural variations, and regulatory changes that drive tumor behavior. This review by Brian Tait, Chief Scientific…
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Single-Chromosome Sequencing in Human Cancers: A Window into Gene-Specific Tumor Biology
Introduction: Why Focus on a Single Chromosome? Cancer genetics has traditionally relied on bulk genome analyses, which average signals across millions of cells. While informative, this approach can obscure rare but functionally critical events occurring on individual chromosomes. The idea of single-chromosome sequencing—an approach that isolates and analyzes one chromosome at a time—offers a rare…