Tag: cancer genetics
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Immune-Related Genes Shape Pancreatic Cancer Risk and Outcomes Identified
Groundbreaking Discovery in Pancreatic Cancer Genetics Researchers at the National Cancer Research Centre (CNIO) have identified immune-related genetic variants that influence both the risk of developing pancreatic ductal adenocarcinoma (PDAC) and the disease’s survival outcomes after diagnosis. This large-scale genetic analysis highlights how the immune system’s genetic blueprint can shape cancer susceptibility and progression, offering…
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Ontario Launches Large-Scale Genetic Screening to Detect Hereditary Cancer and Cholesterol-Linked Risk
Ontario to Screen 100,000 for Hereditary Cancer and Cholesterol-Linked Risk A landmark genetic screening project announced by the Princess Margaret Cancer Centre will screen up to 100,000 residents of Ontario over the next five years. The initiative aims to identify individuals with inherited cancer risks and conditions tied to high cholesterol and heart disease, enabling…
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Single-Chromosome Sequencing in Human Cancers: Key Genes and Insights
Introduction: A focused lens on cancer genomics The field of cancer genetics is rapidly evolving, with researchers seeking methods that offer high-resolution insights while managing complexity. Single-chromosome sequencing represents a focused approach that targets individual chromosomes to reveal mutations, structural variations, and regulatory changes that drive tumor behavior. This review by Brian Tait, Chief Scientific…
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Single-Chromosome Sequencing in Human Cancers: A Window into Gene-Specific Tumor Biology
Introduction: Why Focus on a Single Chromosome? Cancer genetics has traditionally relied on bulk genome analyses, which average signals across millions of cells. While informative, this approach can obscure rare but functionally critical events occurring on individual chromosomes. The idea of single-chromosome sequencing—an approach that isolates and analyzes one chromosome at a time—offers a rare…