Tag: cancer biology
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IFITM3-MET Interaction Drives Osimertinib Resistance in EGFR-Mutant NSCLC
Overview: A New Mechanism Behind Osimertinib Resistance in EGFR-Mutant NSCLC Osimertinib has transformed the treatment landscape for patients with EGFR-mutant non-small cell lung cancer (NSCLC). Yet resistance remains a major hurdle. A recent study identifies a non-genetic mechanism: the membrane protein IFITM3 interacts with MET to activate the PI3K-AKT signaling axis, enabling tumor cells to…
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IFITM3-MET Interaction Drives Osimertinib Resistance in NSCLC
Overview: A cytokine-driven route to osimertinib resistance in EGFR-mutant NSCLC Osimertinib has transformed treatment for patients with EGFR-mutant non-small cell lung cancer (NSCLC) but resistance remains a critical hurdle. A combination of clinical data, tumor profiling, and functional studies now implicates IFITM3, a small antiviral membrane protein, in mediating resistance. The key finding is that…
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Cancer Cells’ Hidden Power Source Revealed
Introduction: A surprising energy boost under pressure Scientists have uncovered a surprising mechanism that helps cancer cells survive the brutal mechanical gauntlets they must run to spread through the body. When cancer cells squeeze through dense tumor matrices, pores in blood vessels, and the bloodstream itself, they encounter intense physical stress. A team at the…