Tag: Breast Cancer
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SUPREMO Trial: Rethinking Postmastectomy Radiotherapy
Overview: A Shift in Postmastectomy Strategy The international phase 3 SUPREMO trial is reshaping how clinicians treat intermediate-risk early breast cancer (eBC) after mastectomy. The study, officially registered as ISRCTN61145589, investigated whether omitting chest-wall irradiation could maintain survival outcomes while reducing treatment-related toxicity. Historically, postmastectomy radiotherapy (PMRT) has been standard care for various levels of…
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Modern Therapies Challenge Radiation’s Role in Early Breast Cancer Survival
Rethinking Postmastectomy Radiation in Early Breast Cancer New evidence from the international phase 3 SUPREMO trial is prompting clinicians to rethink the standard use of chest-wall irradiation after mastectomy for patients with intermediate-risk early breast cancer (eBC). The study explored whether omitting radiotherapy could maintain survival while reducing treatment-related harms, a question that directly affects…
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Global survey reveals the unique challenges of young breast cancer patients with children
Overview: A Global Spotlight on Young Women with Advanced Breast Cancer A groundbreaking global survey conducted by ABC Global Alliance sheds light on the distinctive challenges faced by young women under 40 living with advanced breast cancer who also juggle motherhood. The study, the first of its kind to specifically examine this group, finds that…
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ABC8: Global survey highlights challenges facing young breast cancer patients
Global survey sheds light on a hidden struggle A groundbreaking global survey, conducted in collaboration with the ABC Global Alliance, reveals the unique pressures faced by women under 40 living with advanced breast cancer. For the first time, researchers quantify how many of these women are also mothers and outline the multifaceted challenges they confront…
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Young breast cancer patients worldwide face major challenges
Overview: A global lens on young women with advanced breast cancer A landmark global survey conducted by the ABC Global Alliance sheds light on the specific, often overlooked challenges faced by young women under 40 who live with advanced breast cancer. For the first time, researchers have documented not only medical needs but also the…
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Why Some Breast Cancers Resist Antibody Drug Conjugates (ADCs)
Unraveling Resistance to Antibody Drug Conjugates in Breast Cancer Antibody drug conjugates (ADCs) represent a promising class of targeted cancer therapies that couple a tumor-homing antibody with a potent cytotoxic payload. In breast cancer, this approach aims to deliver chemotherapy directly to malignant cells while sparing most healthy tissue. Yet, not all patients respond, and…
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New Insights into Why Some Breast Cancers Resist Antibody-Drug Conjugates (ADCs) Therapy
Understanding ADCs and Why They Matter in Breast Cancer Antibody‑drug conjugates (ADCs) are a cutting‑edge class of cancer therapies designed to target malignant cells with precision. By pairing a cancer‑specific antibody with a potent cytotoxic drug, ADCs aim to destroy tumor cells while limiting damage to healthy tissue. In breast cancer, ADCs have shown promise,…
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Why Some Breast Cancers Resist Antibody Drug Conjugates: New Mayo Clinic Insights
Understanding the Challenge: Breast Cancer and Antibody Drug Conjugates Antibody drug conjugates (ADCs) represent a promising class of targeted cancer therapies. They couple a cancer-seeking antibody with a potent cytotoxic drug, delivering treatment directly to tumor cells while aiming to spare healthy tissue. In breast cancer, these therapies have shown notable potential, especially for tumors…
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Breast Cancer: Radiation May Be Unnecessary for Many Patients
New findings question the routine use of radiation in early breast cancer Radiation therapy has long been a cornerstone of breast cancer treatment, helping to reduce local recurrence after surgery. In recent years, however, many doctors have begun reevaluating its role for patients with early-stage disease. Advances in imaging, tumor biology, and systemic therapies have…
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Radiation May Be Unnecessary for Many Breast Cancer Patients
Reconsidering a long-standing standard Radiation therapy has been a cornerstone of breast cancer treatment for decades, particularly after breast-conserving surgery. Its role has been to destroy remaining cancer cells, reduce the risk of local recurrence, and improve long-term survival. Yet in recent years, advances in diagnostics, pathology, and systemic therapies have allowed clinicians to reevaluate…