Tag: brain aging
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HPO Axis & Brain Aging: Ovarian Disorders & Neurodegeneration
Understanding the HPO Axis in Female Health The hypothalamic-pituitary-ovarian (HPO) axis is a finely tuned endocrine feedback loop that governs ovulation and reproductive function in female vertebrates. Proper balance relies on the regulated secretion of sex steroids by the ovarian follicle to inhibit pulsatile release of gonadotropins from the pituitary. Disruptions in any component of…
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HPO Axis and Brain Aging: Ovarian Disorders Explained
Introduction: Connecting the HPO Axis to Brain Aging The hypothalamic‑pituitary‑ovarian (HPO) axis sits at the center of female reproductive health, orchestrating ovulation through a delicate balance of hormones. Recent reviews highlight how disruptions in this axis not only drive ovarian disorders such as menopause, primary ovarian insufficiency (POI), and polycystic ovary syndrome (PCOS) but may…
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The HPO Axis, Ovarian Disorders, and Brain Aging: Connecting Reproductive Health to Neurodegeneration
Understanding the HPO Axis and Its Role in Reproductive Health The hypothalamic-pituitary-ovarian (HPO) axis is a finely tuned endocrine system that governs female reproduction. It starts in the hypothalamus, where gonadotropin-releasing hormone (GnRH) prompts the pituitary to secrete luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones, in turn, regulate ovarian follicle development and the…
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Ireland study suggests HRT after menopause may lower dementia risk for women
New Irish findings connect lifetime oestrogen exposure and dementia risk A new study from Ireland suggests that women who maintain higher exposure to oestrogen across their lives—and those who use hormone replacement therapy (HRT) after menopause—may face a lower risk of developing dementia. Led by Dr Emer McGrath, an associate professor of medicine at the…
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EPG5 Gene Errors Tied to Vici Syndrome and Parkinson’s
New Links Between EPG5 Mutations, Early Neurodevelopment, and Later Neurodegeneration A groundbreaking study connects errors in the EPG5 gene, already known for causing the rare neurodevelopmental disorder Vici syndrome, to later-age neurodegenerative conditions such as Parkinson’s disease and dementia. Published in the Annals of Neurology, the research consortium spanning King’s College London, University College London…
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Brain shape changes linked to dementia: MRI findings
Brain shape changes as a potential early signal for dementia A new study published in Nature Communications on September 29 reveals that the aging brain’s shape, not just its tissue loss, shifts in systematic ways that correlate with cognitive function. The research suggests that magnetic resonance imaging (MRI) can capture these geometric changes, which may…
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Poor Sleep May Accelerate Brain Aging, Study Finds
Poor sleep may accelerate brain aging, new findings suggest In a large study led by researchers at Karolinska Institutet, scientists explored how everyday sleep habits relate to the aging of the brain. Using data from 27,500 middle-aged and older adults in the UK Biobank, the team estimated brain age with machine learning on more than…
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Poor Sleep Health May Accelerate Brain Aging, KI Study Finds
Overview: poor sleep and the aging brain Bad sleep has long been associated with dementia risk, but it remains unclear whether unhealthy sleep habits drive brain aging or simply reflect early disease symptoms. A large study from Karolinska Institutet addresses this question by examining how sleep patterns relate to brain aging in relation to chronological…
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Poor Sleep Health Linked to Faster Brain Aging Across Adults
Why sleep quality may influence brain aging Emerging evidence suggests that how well we sleep might not only affect how rested we feel, but also how quickly our brains age. In a large UK-based study led by researchers at Karolinska Institutet, scientists explored whether unhealthy sleep patterns are connected to an older-looking brain, as measured…