Tag: bioprocessing
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Suspension Cultivation of Mosquito Cells for Usutu Virus: Implications for Bioreactor-Based Production
Overview: Usutu virus and the role of mosquito cell lines Usutu virus (USUV) is a mosquito-borne flavivirus related to West Nile virus that circulates mainly among birds and mosquitoes, with occasional human infections. Research into USUV often relies on cell culture systems to study viral replication, host range, and pathogenesis, as well as to support…
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Mosquito Cell Line Bioreactors: Usutu Virus Production and Future Arboviral Vaccines
Understanding Usutu Virus and Arboviral Threats Usutu virus, a mosquito-borne flavivirus related to West Nile virus, has emerged as a growing concern for public health in certain regions. While most infections are mild or asymptomatic, Usutu virus can cause neurological illness in rare cases and has demonstrated the potential for rapid geographical spread. In tandem…
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MIT Engineers Unstick Cells on Demand With Bubble-Driven Detachment in Bioreactors
Revolutionizing cell adhesion in bioreactors and beyond MIT researchers have unveiled a scalable, high-throughput method to detach cells from surfaces on demand using electrochemically generated bubbles. Published in Science Advances, the approach could dramatically reduce downtime and waste across industries that rely on cell cultures, including algae bioreactors for carbon capture, pharmaceutical manufacturing, biofuels, biosensors,…
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MIT Engineers Solve Sticky-Cell Problem in Bioreactors
Overview: Tackling a universal bottleneck in cell-based production Bioreactors are central to modern manufacturing, from growing algae that aggressively absorb CO2 to producing biologic drugs and cell therapies. But a stubborn challenge—cells sticking to surfaces—limits performance across industries. This adhesion reduces light exposure in photobioreactors, disrupts harvesting, and triggers costly downtime for cleaning. A new…
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MIT Engineers Solve Sticky-cell Problem In Bioreactors And Other Industries
Introduction: A Simple Problem, Big Impact Bioreactors and related processes across industries—from algae farming in climate-friendly carbon capture efforts to manufacturing biologic drugs—face a stubborn obstacle: cells sticking to surfaces. This adhesion reduces light exposure in photobioreactors, clogs harvesting lines, and forces costly downtime for cleaning and sanitation. MIT researchers have now introduced a high-throughput,…