Tag: Biomarkers
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Inflammasome Proteins Offer New Path in Pediatric Traumatic Brain Injury Assessment
Breakthrough in Pediatric TBI Evaluation: Biomarkers ASC and caspase-1 A new study published in Nature Pediatric Research highlights a promising biomarker-based approach to assessing pediatric traumatic brain injury (TBI). Led by Dr. Jennifer Muñoz Pareja, the research examines serum inflammasome proteins ASC and caspase-1, revealing that their levels rise significantly in children with TBI and…
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Inflammasome Proteins Improve Pediatric Traumatic Brain Injury Assessment
New Biomarkers Offer Fresh Insight into Pediatric TBI Pediatric traumatic brain injury (TBI) remains a major medical challenge with potential long‑term cognitive, behavioral, and motor consequences. A groundbreaking study published in Nature Pediatric Research introduces a serum biomarker approach that could transform how clinicians evaluate injury severity and guide treatment in children. Led by Dr.…
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Genetic Resilience: A Distinct COPD Subtype In Smokers With High Genetic Risk
Understanding Genetic Resilience in COPD COPD shows substantial variability in how it develops among people who smoke. While a genetic risk score helps predict who is more likely to develop COPD, many individuals with high genetic risk do not actually develop the disease. Recent research introduces the concept of genetic resilience to COPD—a clinically meaningful…
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Longevity Breakthrough: Oxytocin + A5i Extend Lifespan
Overview New research suggests a dual-drug approach could unlock longer life in aging organisms. In a study published in Ageing-US, scientists explored a combination therapy using oxytocin and OT+A5i, a compound that blocks a key growth-regulating pathway. The aim: slow aging processes and improve healthspan by addressing two biological pathways that change with age. The…
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New MAEA function could help overcome chemo resistance in cancer treatment
New MAEA function in DNA repair offers a potential route to overcoming chemotherapy resistance A University of Alberta research team has identified a surprising new role for a protein once thought to be linked primarily to red blood cell development. The protein, macrophage erythroblast attacher (MAEA), appears to help regulate DNA repair and cell replication.…
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New Evidence on Heart Failure in AML Treated with Anthracyclines: What Clinicians Need to Know
Overview Heart failure in AML remains a critical concern for patients undergoing induction therapy with anthracycline-based regimens. A comprehensive meta-analysis led by researchers in the Netherlands analyzed 41 studies totaling 5,995 AML patients. The study quantified the burden of heart failure and highlighted substantial variability depending on the specific anthracycline used. These findings reinforce the…
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Digital Cognitive Test and Blood Biomarkers for Alzheimer’s
Two-step workflow could reshape Alzheimer’s detection in primary care A recent study published in Nature Medicine proposes a practical, scalable approach to diagnosing Alzheimer’s disease (AD) in everyday clinics: first confirm cognitive impairment with a brief digital tool, then use a targeted blood biomarker panel to verify amyloid pathology. This “test then blood” strategy aims…
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Digital test plus blood biomarker boosts accuracy of Alzheimer’s diagnosis in primary care
Two-step workflow taps cognitive screening before biomarker testing A new two-step approach to diagnosing Alzheimer’s disease (AD) in primary care shows promise for cutting false positives and streamlining referrals. Researchers tested a brief, self-administered digital cognitive battery, BioCog, first, and reserved amyloid-related blood tests for individuals who showed objective impairment. This “test-then-blood” workflow aims to…
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Decoding Signaling Networks and Metabolic Dysregulation in Sepsis
Understanding Sepsis: A Web of Signaling and Metabolism Sepsis is a life-threatening syndrome arising from infection that triggers a dysregulated immune response and widespread organ dysfunction. Modern research paints a picture of sepsis not as a single pathway anomaly but as a complex network of interlocking signaling cascades and metabolic changes. Central to this network…
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Can a new blood test really detect ME/CFS? An expert unpacks new research
New blood test for ME/CFS: exciting but early days Researchers in the United Kingdom say they have developed a blood test that might diagnose myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) with about 96% overall accuracy. If validated in larger groups, this could be the first objective tool to support the long, often frustrating process of ME/CFS…