Tag: autoimmune encephalitis
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When Misdiagnosis Strikes: Autoimmune Encephalitis Misread as Bipolar Disorder
Introduction: A Diagnostic Dilemma In recent years, a relatively new class of autoimmune diseases that attack the brain has prompted psychiatrists and neurologists to reconsider some long-held diagnostic assumptions. Autoimmune encephalitis, though uncommon, often begins with psychiatric symptoms that resemble mood disorders, psychosis, or anxiety. This overlap can lead to misdiagnosis, delayed treatment, and ongoing…
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When Autoimmune Encephalitis Masquerades as Bipolar Disorder
Understanding the Diagnostic Dilemma In recent years, a relatively new class of autoimmune diseases that attack the brain has prompted psychiatrists to rethink traditional diagnoses. Autoimmune encephalitis, though uncommon, can present with a spectrum of psychiatric symptoms such as mood swings, paranoia, anxiety, and psychosis. These manifestations often precede or eclipse more typical neurological signs,…
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When Autoimmune Encephalitis Mimics Mental Illness: A Hidden Diagnosis Behind Psychiatric Symptoms
Understanding the Diagnostic Challenge In recent years, a relatively new class of autoimmune diseases that affect the brain has led psychiatrists to reconsider traditional diagnostic boundaries. Autoimmune encephalitis occurs when the body’s immune system mistakenly targets brain tissue, triggering a range of neurological and psychiatric symptoms. While the condition remains rare, its impact is profound…
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Cryo-EM Maps Find Autoantibody Hotspots on NMDA Receptors
New insights into anti-NMDAR encephalitis Researchers have long sought to understand why the brain’s immune system sometimes attacks the N-methyl-D-aspartate receptor (NMDAR), triggering a dangerous condition known as autoimmune encephalitis or “Brain on Fire.” A recent study published in Science Advances uses high-resolution Cryo-Electron Microscopy (Cryo-EM) to map where autoantibodies latch onto NMDA receptors. The…
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Cryo-EM Maps Autoantibody Hotspots on NMDA Receptors in Autoimmune Encephalitis
New Cryo-EM insights reveal antibody hotspots on NMDA receptors Researchers have leveraged cutting-edge Cryo-Electron Microscopy (Cryo-EM) to pinpoint where autoantibodies most often target NMDA receptors in anti-NMDAR encephalitis. This autoimmune condition, often described in public health circles as “Brain on Fire,” arises when the body’s immune system mistakenly attacks NMDA receptors in the brain, disrupting…
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Cryo-EM Maps Spotlight Autoantibody Hotspots on NMDA Receptors for Anti-NMDAR Encephalitis Therapies
New Insights into Anti-NMDAR Encephalitis Autoimmune encephalitis linked to anti-NMDA receptor (NMDAR) antibodies has earned the nickname “Brain on Fire” for its dramatic neuropsychiatric symptoms and rapid progression. A groundbreaking study published in Science Advances leverages cryo-electron microscopy (cryo-EM) to map where autoantibodies most often bind on the NMDAR complex. The findings offer a clearer…