Overview of the December 2025 TAG-CO-VAC Deliberations The World Health Organization’s Technical Advisory Group on COVID-19 Vaccine Composition (TAG-CO-VAC) continues to monitor the genetic and antigenic evolution of SARS-CoV-2, how the immune system responds to infection and vaccination, and how vaccines perform against circulating variants. Ahead of the December 2025 decision-making meeting, TAG-CO-VAC outlines the…