Tag: Alzheimer’s Disease
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Lighthouse Pharmaceuticals to Present Phase 2 SPRING Trial of LHP588 for P. gingivalis–Positive Alzheimer’s at CTAD 2025
Overview: A Targeted Approach to a Complex Neurodegenerative Challenge In a bid to address an emerging and controversial hypothesis in Alzheimer’s disease (AD) research, Lighthouse Pharmaceuticals announced the Phase 2 SPRING trial results for LHP588, a next-generation gingipain inhibitor, at the Clinical Trials on Alzheimer’s Disease (CTAD) 2025 conference. The company positions LHP588 as a…
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Tau Fibril Formation Boosted by Polymer Physics Insights
Introducing a fresh lens on Alzheimer’s pathology In a groundbreaking cross-disciplinary venture, researchers from Tokyo Metropolitan University have adapted concepts from polymer physics to shed new light on the tau protein fibril formation that characterizes a key pathology in Alzheimer’s disease. By borrowing ideas about how polymers behave at the mesoscopic scale, the team aims…
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Polymer Physics Illuminates Tau Fibril Formation in Alzheimer’s Disease
Unlocking a Key Alzheimer’s Pathology with Polymer Physics Researchers from Tokyo Metropolitan University are applying concepts from polymer physics to unravel a central mystery of Alzheimer’s disease: how tau proteins assemble into the fibrillar structures that destabilize neurons. By treating tau aggregates as dynamic, filament-forming polymers, the team aims to map the steps that precede…
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Polymer Physics Sheds Light on Tau Fibril Formation in Alzheimer’s
New Cross-Disciplinary Insight into Alzheimer’s Pathology Researchers at Tokyo Metropolitan University have bridged fields by applying concepts from polymer physics to the study of tau protein fibrillogenesis, a central feature of Alzheimer’s disease pathology. By treating tau proteins as dynamic polymers that can assemble, rearrange, and crystallize under cellular conditions, the team is uncovering the…
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Newly Identified Microglia Subtype Offers Protection Against Alzheimer’s Disease
Groundbreaking discovery: a protective microglia subtype In the ongoing effort to understand Alzheimer’s disease, researchers are turning the spotlight onto the brain’s immune sentinels: microglia. A newly identified subtype of these cells appears to play a protective role in the brain, potentially slowing the progression of Alzheimer’s disease. The finding, emerging from collaborations led by…
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Scientists Edge Toward Reversing Memory Loss in Aging Brains with Gene Editing
New Frontiers in Memory and Aging Scientists are moving closer to a breakthrough in how aging brains can regain memory function. In two complementary studies led by Timothy Jarome, associate professor in the College of Agriculture and Life Sciences’ School of Animal Sciences, researchers used advanced gene-editing tools to target molecular changes associated with memory…
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New Microglia Subtype Could Shield Against Alzheimer’s Disease
Groundbreaking Discovery in Brain Immunity In the ongoing battle against Alzheimer’s disease, scientists have uncovered a new subtype of microglia—the brain’s resident immune cells—that appears to shield neural tissue from early damage. The finding, reported by researchers at the Icahn School of Medicine at Mount Sinai, adds a promising piece to the complex puzzle of…
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A New Microglia Subtype May Shield the Brain from Alzheimer’s
Breaking Discovery: A Protective Microglia Subtype Emerges In the ongoing quest to understand Alzheimer’s disease, scientists have long watched the brain’s resident immune cells, microglia, as both guardians and potential aggressors. A recent study by researchers at the Icahn School of Medicine at Mount Sinai, in collaboration with other institutions, has identified a distinct microglia…
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How Alzheimer’s Disease May Disrupt Brain-Fat Communication, Elevating Cardiometabolic Risk
Overview: The Brain-Fat Axis under Strain Alzheimer’s disease (AD) is widely known for its cognitive toll, but emerging research suggests its reach extends into the body’s metabolic and cardiovascular systems. A study from Houston Methodist points to a troubling possibility: Alzheimer’s disease may hijack the brain’s ability to regulate fat tissue and overall energy metabolism.…
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Alzheimer’s Disease May Hijack Fat Tissue Communication, Worsening Metabolism
Understanding the connection between Alzheimer’s disease and metabolic regulation Alzheimer’s disease is widely recognized for its impact on memory and cognition, but emerging research suggests the condition may extend its reach into how the body manages energy and fats. A growing body of evidence indicates that Alzheimer’s can disrupt the dialogue between the brain and…