Tag: Alzheimer’s Disease
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Improving Brain Resilience: Rab Proteins and Future Treatments
How Rab Proteins Orchestrate Synaptic Potentiation Memory formation hinges on synaptic potentiation—the strengthening of connections between neurons. This growth is driven by a tightly coordinated delivery system within neurons that supplies the building blocks essential for remodeling synapses. A large family of cellular switches, known as Rab proteins, governs the flow of these supplies, directing…
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Nemours Neurologist Wins NIH Award to Study Hippocampal Dysfunction Across Autism, Epilepsy, and Alzheimer’s
Nemours Neurologist Secures Prestigious NIH Transformative Research Award A leading physician-scientist at Nemours Children’s Health has been awarded a National Institutes of Health (NIH) Director’s Transformative Research Award. Rodney Scott, MBChB, MRCP, DipStat, PhD, serves as Division Chief of Neurology for the Nemours Delaware Valley region and will channel a $2.6 million, five-year grant into…
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Fetal Immune Activation Shapes Memory Aging: Sex Differences
Intro: How early brain development influences aging and memory Population aging in the United States is accelerating, with projections showing a growing share of adults aged 65 and older. While lifestyle, genetics, and health conditions influence memory in later life, mounting evidence points to prenatal periods as a foundational phase that can shape memory circuits…
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Fetal Origins of Memory Impairment: Sex Differences in Aging
Overview: How early-life factors shape memory in later life New evidence suggests that critical processes during fetal brain development can influence memory and cognitive resilience decades later. Researchers led by Jill Goldstein, PhD, MPH, from the Innovation Center on Sex Differences in Medicine at Mass General are examining how sex and reproductive history modulate the…
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Digital Test Plus Blood Biomarker Improves Primary Care Alzheimer’s Diagnosis
New Frontline Approach to Alzheimer’s Diagnosis in Primary Care A two-step strategy combining a brief, self-administered digital cognitive test with a targeted blood biomarker panel dramatically improves the accuracy of Alzheimer’s disease (AD) diagnosis in everyday clinics. The approach, validated in a recent Nature Medicine study, shows that confirming cognitive impairment before ordering amyloid blood…
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Digital test plus blood biomarker boosts accuracy of Alzheimer’s diagnosis in primary care
Two-step workflow taps cognitive screening before biomarker testing A new two-step approach to diagnosing Alzheimer’s disease (AD) in primary care shows promise for cutting false positives and streamlining referrals. Researchers tested a brief, self-administered digital cognitive battery, BioCog, first, and reserved amyloid-related blood tests for individuals who showed objective impairment. This “test-then-blood” workflow aims to…
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Investigating cannabidiol’s role in combating Alzheimer’s-related neuroinflammation
Background: the inflammation link in Alzheimer’s disease Alzheimer’s disease is commonly discussed in terms of plaques and tangles, but neuroinflammation is increasingly recognized as a driving force in its progression. Chronic immune activation within the brain can damage neurons and contribute to cognitive decline. Cannabidiol (CBD), a non-psychoactive component of cannabis, has demonstrated anti-inflammatory properties…
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Cannabidiol Shows Promise in Reducing Alzheimer’s-Related Neuroinflammation in Mouse Model
Overview: CBD as a potential anti-inflammatory strategy for Alzheimer’s disease Neuroinflammation is increasingly recognized as a central driver of neuronal damage in Alzheimer’s disease (AD). While the classic hallmarks of AD—amyloid plaques and tau tangles—have guided much research, chronic immune activation within the brain also accelerates cognitive decline. A new study in eNeuro by Babak…
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CBD and Alzheimer’s: Combatting Neuroinflammation in Mice
Understanding the link between neuroinflammation and Alzheimer’s Neuroinflammation is increasingly recognized as a pivotal driver of neuronal damage in Alzheimer’s disease. While much attention has centered on amyloid plaques and tau tangles, chronic immune activation within the brain—often driven by microglia and other glial cells—can accelerate neurodegeneration. A growing body of work suggests that modulating…
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Fat May Secretly Fuel Alzheimer’s: Obesity Tied to Brain Plaque via Adipose Vesicles
Obesity, tiny messengers, and a potential Alzheimer’s link In a pioneering study from Houston Methodist, researchers propose that adipose-derived extracellular vesicles—tiny, cell-to-cell messengers circulating in the body—may signal the brain to form amyloid-β plaques, a hallmark of Alzheimer’s disease. Published on October 2 in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, the work…