Overview
The Yale Journal of Biology and Medicine (YJBM) announces a targeted issue focused on mitochondria in health and disease. This call for manuscripts invites researchers to contribute original research, reviews, brief reports, and methodological papers that advance understanding of mitochondrial biology, cellular energy, and their roles in health outcomes and disease processes. The issue aims to synthesize mechanistic insights with translational perspectives, highlighting how mitochondrial function influences metabolism, aging, neurodegeneration, cancer, and cardiovascular health.
Why Mitochondria Matter
Mitochondria are more than powerhouses of the cell. They orchestrate apoptosis, regulate metabolic flux, generate reactive oxygen species, and interact with other organelles to shape cellular fate. Disruptions in mitochondrial dynamics, genetics, and quality control contribute to a wide spectrum of diseases, from rare mitochondrial disorders to common conditions such as Alzheimer’s disease, Parkinson’s disease, diabetes, obesity, and cardiomyopathies. This issue seeks papers that illuminate these connections with rigor, novelty, and clinical relevance.
Potential Topics
- Genetic and epigenetic regulation of mitochondrial function
- Mitophagy, mitochondrial biogenesis, and quality control mechanisms
- Mitochondrial dynamics in development and aging
- Mitochondria and metabolism in cancer biology
- Role of mitochondria in neurodegenerative diseases and neuroinflammation
- Cardiovascular implications of mitochondrial dysfunction
- Inter-organellar communication and mitochondrial signaling
- Therapeutic strategies targeting mitochondria (drugs, gene therapy, lifestyle interventions)
Submission Details
Submission Deadline: June 1, 2026. Accepted manuscripts will be considered for publication in the September 2026 issue. Authors are encouraged to submit original research articles, comprehensive reviews, brief reports, case reports with broader implications, and methodological papers that improve mitochondrial research techniques.
Manuscripts should clearly connect mitochondrial biology with health outcomes or disease mechanisms and adhere to YJBM’s guidelines for structure and formatting. Submissions will undergo standard peer review with emphasis on scientific rigor, novelty, and translational significance.
Why Submit to YJBM
YJBM provides a reputable platform for disseminating interdisciplinary findings to clinicians, researchers, and students. The mitochondria-focused issue offers a cohesive theme that can amplify visibility within the biomedical community, encourage cross-disciplinary dialogue, and accelerate the translation of basic discoveries into potential therapies.
How to Prepare Your Manuscript
- Prepare manuscripts in accordance with YJBM guidelines, including abstract, introduction, methods, results, discussion, and references.
- Highlight the translational relevance of mitochondrial findings and their impact on health and disease.
- Provide clear figures and statistical analyses that support key conclusions.
- Ensure that data availability and ethical standards are transparently reported.
Editorial Process and Timeline
Upon submission, manuscripts will undergo initial editorial screening for scope and quality. Eligible contributions are then reviewed by at least two independent experts. The editorial team aims to provide timely feedback and maintain transparent communication throughout the process. Authors will be notified of decisions and revisions required as part of the standard workflow.
Publication Date
The mitochondria in health and disease issue is scheduled for publication in September 2026. Submissions aligned with this timeline will be considered for inclusion in the issue’s curated collection.
Contact and Submission
For author guidelines and submission instructions, please visit the YJBM submissions portal or contact the editorial office with any questions related to scope, formatting, or timelines. This is an excellent opportunity to contribute to a focused, high-impact discussion on mitochondrial biology and its implications for human health.
