Overview: Florio vs. Simms in Week 6 NFL Picks
Week 6 of the 2025 NFL season brings a familiar clash on Pro Football Talk: Mike Florio and co-hosts facing off against the trusted opinion of former quarterback-turned-analyst Chris Simms. After a rough stretch last week for Florio, both pundits return with a slate that could swing the standings, especially as the season hits the point where injury reports, momentum, and home-field effects become pivotal. The objective remains clear: pick winners, cover the spread where possible, and provide readers with a readable, data-informed forecast for each matchup.
Week 6 Matchups: A Game-by-Game Preview
Below is a concise breakdown of the games where Florio and Simms disagree or align, along with insights on potential pivots in the spread and point totals. The focus is on how these choices reflect deeper trends in the 2025 season, including quarterback play, coaching adjustments, and late-season form.
Eagles (-7) at Giants
The short week adds a wrinkle for Philadelphia as they try to stabilize their offense. Florio projects a win with a modest margin, while Simms expects a slightly higher scoring effort. Expect the Eagles to lean on their ground game and play-action to stretch the Giants’ defense. This game tests whether the Eagles can convert red-zone opportunities and protect the football under pressure.
Broncos (-7.5) vs. Jets at London
London games often distort travel calendars and energy. Florio sees Denver taking control early, with a defensive ledger that limits big plays from the Jets. Simms outlines a similar outcome but with a touch more scoring late. The Broncos’ improved rhythm on offense, coupled with an aggressive home crowd, could push this spread toward the middle or beyond.
Rams (-7.5) at Ravens
Two teams trying to reframe seasons collide in Baltimore. Florio’s Rams pick hinges on a sharper pass rush and more efficient offense, while Simms expects continued struggles from the Ravens at home. This game centers on situational football, including third-down efficiency and red-zone execution.
Cowboys (-3) at Panthers
The Cowboys’ ability to impose pace and control the line of scrimmage is the focal point here. Florio projects a win that subtly extends their march toward a playoff berth, while Simms anticipates a closer clash. Panthers will need a reliable running game and turnover margins to stay within striking distance.
Cardinals at Colts (-7)
Two offenses built around playmaking will face each other, but the Colts’ depth and coaching edge are expected to surface. Florio leans Colts, while Simms agrees but anticipates a more comfortable margin than the spread implies. Keep an eye on special teams and field-position battles.
Seahawks at Jaguars (-1.5)
The Jaguars look legit on both sides of the ball, with the Seahawks posing a credible challenge. Florio’s pick points to Jacksonville’s home-field advantage and a disciplined game plan. Simms expects a higher-scoring affair, underscoring the competitiveness of the AFC South–NFC showdown.
Chargers (-4.5) at Dolphins
Injury news and the Dolphins’ environmental advantages could tilt this toward an entertaining shootout. Florio calls for a Chargers win with a narrow margin, while Simms is slightly more pragmatic, projecting a close result given the injuries and travel strain on the Chargers’ defense.
Patriots (-3.5) at Saints
Both teams trend toward the postseason conversation, with New England’s quarterback room getting more efficient. Florio’s stance favors the Pats, with Simms aligning but with a tighter margin, reflecting a potentially low-scoring, field-position battle.
Browns at Steelers (-5.5)
Ariations at quarterback play shape this one, with the Steelers favored to control the clock and pressure the Browns. Florio’s read leans Steelers, while Simms’s projection mirrors that conclusion, both expecting Pittsburgh to win and cover in a tough divisional matchup.
Titans at Raiders (-3.5)
The Raiders seem to capture momentum at home, though Titans’ resilience could alter late twists. Florio sees a Raiders win with a comfortable margin; Simms predicts a similar outcome with a modestly tighter score.
Other notable games
Packers at Bengals, 49ers at Buccaneers, Lions at Chiefs, Bills at Falcons, Bears at Commanders—these games carry implications for divisional races and wild-card positioning. Florio and Simms often disagree by margins that reflect differing takes on quarterback efficiency, injuries, and weekend weather expectations.
Why Week 6 Matters for Your Fantasy and Betting Strategy
Beyond pure analytics, Week 6 is a snapshot of how teams adapt after the first quarter of the season. For bettors, listening to Florio and Simms offers a gauge of public sentiment and hedging opportunities. For fantasy players, the selections hint at which offenses could proliferate, which defenses might bend but not break, and where opportunity lies for breakout performances.
Final thoughts from Florio and Simms
As always, the best wager is disciplined, responsible betting. Florio and Simms deliver a mix of bold predictions and cautionary notes, reminding readers that even seasoned analysts can miss a week. The 2025 season remains unpredictable, and Week 6 should provide ample drama, dustups, and—likely—some upsets that shift momentum for the rest of the year.
